姓名：范明性别：男职称：研究员、教授招生院所：基础医学院招生类型：科学学位(博)科学学位(硕)招生专业：神经生物学(博)神经生物学(硕)研究方向名称：低氧等环境因素对神经肌肉发育与损伤修复的作用与机制电子信箱：fanmingchina@126.com

社会任职

1.全国应用生理专业委员会主任委员

2.亚太地区高原医学会常务理事

3.中国神经科学会常务理事

个人简历

1.197610-198007:北京第二医学院医疗四系学生

2.198009-198307:军事医学科学院硕士

3.198509-198807:军事医学科学院博士

4.1989-1993:军事医学科学院基础医学研究所副研究员

5.1993-:军事医学科学院基础医学研究所研究员

6.2006-:首都医科大学客座教授

重要学术论文

1.DingXF,ZhaoYQ,FanWH,WuLY,HuangX,WangF,HeYL,LiuSH,WuY,ZhaoT,WuY,ZhuLL,FanM..Genetransferintothebothsidesofpostnatalcerebralcortexusingtweezerelectrode.CNSNeurosciTher..2013,19(3):197-8..SCI

2.WangY,YangJ,LiH,WangX,ZhuL,FanM,WangX..HypoxiapromotesdopaminergicdifferentiationofmesenchymalstemcellsandshowsbenefitsfortransplantationinaratmodelofParkinson'sdisease..PLoSOne..2013,8(1):e54296.SCI

3.XiongL,WangF,HuangX,LiuZH,ZhaoT,WuLY,WuK,DingX,LiuS,WuY,ZhaoY,ZhuLL,FanM.DNAdemethylationregulatestheexpressionofmiR-210inneuralprogenitorcellssubjectedtohypoxia.FEBSJ..2012,279(23):4318-26.SCI

4.DingXF,ZhaoYQ,HuZY,LinK,WangF,LiuSH,WuY,WuLY,ZhaoT,HuangX,WuY,ZhuLL,FanWH,FanM.Efficientgenetransferintoneonatalmousebrainusingelectroporation.NeurochemRes..2012,37(7):1392-8..SCI

5.1.XinHuang,JiaSun,TongZhao,KuiwuWu,KazutadaWatanabe,Zhi-ChengXiao,LinglingZhu,MingFan.LossofNB-3aggravatescerebralischemiabyimpairingneuronsurvivalandneuritegrowth..Stroke.2012,42:2910-2916.SCI

6.2.XiangLi,XuWang,PengZhang,LinglingZhu,TongZhao,ShuhongLiu,YanWu,XiaopingChen,MingFan..Extracellularsignal-regulatedkinase1/2mitogen-activatedproteinkinasepathwayisinvolvedininhibitionofmyogenicdifferentiationofmyoblastsbyhypoxia.ExpPhysiol,.2011,061382:1-8.SCI

7.ZhuLL,ZhaoT,huangX,FanM.Geneexpressionprofilesandmetabolicchangesinembryonicneuralprogenitorcellsunderlowoxygen..CellReprogram..2011,13(2)::113-20..SCI

8.5.XinHuang,Ling-lingZhua,TongZhao,Li-yingWu,Kui-wuWu,MelittaSchachner,Zhi-ChengXiao,MingFan..CHL1negativelyregulatestheproliferationandneuronaldifferentiationofneuralprogenitorcellsthroughactivationoftheERK1/2MAPKpathway..MolecularandCellularNeuroscience.2011,;46::296–307..SCI

9.7.Jun-XiaZheng,YangZheng,HuiZhi,YiDai,Nai-LiWang,Yan-XiongFang,Zhi-YunDu,KunZhang,Ming-MingLi,Li-YingWu,MingFan..New3′,8′′-LinkedBiflavonoidsfromSelaginellauncinataDisplayingProtectiveEffectagainstAnoxia.Molecules.2011,16,:6206-6214.SCI

10.LiMM,WuLY,ZhaoT,XiongL,HuangX,LiuZH,FanXL,XiaoCR,GaoY,MaYB,ChenJJ,ZhuLL,FanM.Theprotectiveroleof5-HMFagainsthypoxicinjury.CellStressChaperones.2011,16(3)::267-73.SCI

11.3.WuLY,MaZM,FanXL,ZhaoT,LiuZH,HuangX,LiMM,XiongL,ZhangK,ZhuLL,FanM.Theanti-necrosisroleofhypoxicpreconditioningafteracuteanoxiaismediatedbyaldosereductaseandsorbitolpathwayinPC12cells.CellStressChaperones.2010,15(4)::387-94.SCI

12.2.ShiCG,WangLM,WuY,WangP,GanZJ,LinK,JiangLX,XuZQ,FanM..Intranasaladministrationofnervegrowthfactorproducesantidepressant-likeeffectsinanimals.NeurochemRes.2010,35(9)::1302-14.SCI

13.1.ZhaoYQ,GaoJT,LiuSH,WuY,LinMT,FanM.Geranylgeranylacetonepreconditioningmayattenuateheat-inducedinflammationandmultiorgandysfunctioninrats.JPharmPharmacol.2010,62(1)::99-105.SCI

14.5.LiuS,TianZ,YinF,ZhaoQ,FanM.Generationofdopaminergicneuronsfromhumanfetalmesencephalicprogenitorsafterco-culturewithstriatal-conditionedmediaandexposuretoloweredoxygen..BrainResBull..2009,80(1-2)::62-8.SCI

15.CancerInvest.ExpressionandfunctionalrolesofSmad1andBMPR-IBingliomadevelopment.CancerInvest.2009,27(7)::734-40.SCI

16.LeiXiong,TongZhao,XinHuang,Ling-lingZhu*,MingFan*..Heatshockprotein90isinvolvedinregulationofhypoxia-drivenproliferationofembryonicneuralstem/progenitorcells..CellStressandChaperones.2009,14:183-192.SCI

17.kuanzhang,TongZhao,XinHuang,Ling-lingZhu,MingFan..PreinductionofHSP70promoteshypoxictoleranceandfacilitatesacclimatizationtoacutehypobarichypoxiainmousebrain..CellStressandChaperones.2009,【未填写卷（期）】:【未填写起止页码】.SCI

18.WuHT,FanJ,ZhuLL,FanM.Sema4CExpressioninNeuralStem/ProgenitorCellsandinAdultNeurogenesisInducedbyCerebralIschemia..Jmolneurosci.2009,【未填写卷（期）】:【未填写起止页码】.SCI

19.ZhangL,ZhengSS,WuHT,WuY,LiuSH,Fan,M,Zhang,J*.IdentificationofBLyS(BLymphocyteStimulator),aNon-Myelin-AssociatedProtein,asaFunctionalLigandforNogo-66Receptor..TheJournalofNeuroscience.2009,29(19):6348–6352.SCI

20.11.JingXT,WuHT,WuY,MaX,LiuSH,WuYR,DingXF,PengXZ,QiangBQ,YuanJG,FanWH,FanM.DIXDC1promotesretinoicacid-inducedneuronaldifferentiationandinhibitsgliogenesisinP19cells.CellMolNeurobiol..2009,29(1)::55-67.SCI

21.10.ZhangK,ZhaoT,HuangX,LiuZH,XiongL,LiMM,WuLY,ZhaoYQ,ZhuLL,FanM.PreinductionofHSP70promoteshypoxictoleranceandfacilitatesacclimatizationtoacutehypobarichypoxiainmousebrain.CellStressChaperones.2009,14(4)::407-15.SCI

22.9.XiongL,ZhaoT,HuangX,LiuZH,ZhaoH,LiMM,WuLY,ShuHB,ZhuLL,FanM.Heatshockprotein90isinvolvedinregulationofhypoxia-drivenproliferationofembryonicneuralstem/progenitorcells..CellStressChaperones.2009,14(2)::183-92.SCI

23.8.WuH,FanJ,ZhuL,LiuS,WuY,ZhaoT,WuY,DingX,FanW,FanM.Sema4Cexpressioninneuralstem/progenitorcellsandinadultneurogenesisinducedbycerebralischemia.JMolNeurosci.2009,39(1-2)::27-39.SCI

24.6.GaoJT,LiuSH,YanYE,WuY,WuHT,XingC,GeXM,WangH,ZhaoYQ,FanM.Quinacrineprotectsneuronalcellsagainstheat-inducedinjury..CellBiolInt.2009,33(8)::874-81.SCI

25.YuS，ZhaoT，Fanming.Hypoxicpreconditioningup-regulatesglucosetransportactivityandglucosetransporter(GLUT1andGLUT3)geneexpressionafteracuteanoxicexposureintheculturedrathippocampalneuronsandastrocytes..Brainresearch.2008,23:22-9.SCI

26.WuLY,WangY,FanM.TheroleofhypoxiainthedifferentiationofP19embryonalcarcinomacellsintodopaminergicneurons..NeurochemRes.2008,33:2118-2125.SCI

27.DingX，FanW，FanM.LocalizationandcellulardistributionofCPNE5inembryonicmousebrain..Brainresearch.2008,11:20-8.SCI

28.TangYY,MaYH,FanYX,FengHB,WangJH,FengSG,LuQL,HuB,LinY,LiJ,ZhangY,WangY,ZhouL,FanM*.Centralandautonomicnervoussysteminteractionisalteredbyshort-termmeditation..ProcNatlAcadSciUSA.2008,105:5609-5613.SCI

29.QiangSun1,YanZhang1,GuangYang2,XiaopingChen3,YingaiZhang1,GuojunCao2,.Transforminggrowthfactor-b-regulatedmiR-24promotesskeletalmuscledifferentiation.NucleicAcidsResearchNucleicAcidsResearch.2008,【未填写卷（期）】:1-10.SCI

30.XuanWang,HaitaoWu,ZhenxingZhang,ShuhongLiu,JianYang,XiaopingChen,MingFan,XiaominWang..EffectsofInterleukin-6,LeukemiaInhibitoryFactor,andCiliaryNeurotrophicFactorontheProliferationandDifferentiationofAdultHumanMyoblasts..CellMolNeurobiol.2008,28:113–124.SCI

31.Yi-YuanTang,YinghuaMa,JunhongWang,YaxinFan,ShigangFeng,QilinLu,QingbaoYu,DanniSui,MaryK.Rothbart,MingFanandMichaelI..PosnerShort-termmeditationtrainingimprovesattentionandself-regulation.PNAS.2008,104:4317152–17156.SCI

32.ZhaoT,Zhangcui-ping,LinglingZhu,FanMing.Hypoxia-drivenproliferationofembryonicneuralstem/progenitorcells--roleofhypoxia-inducibletranscriptionfactor-1alpha..FEBSJ.2008,275(8):1824-34.SCI

33.HaitaoWu,XuanWang,ShuhongLiu,WenhongFan*,MingFan*.Sema4Cparticipatesinthemyogenicdifferentiationinvivoandinvitrothroughp38MAPKpathway..Eur.J.CellBiol..2007,86:331-344.SCI

34.PengZhang,XiaopingChen,MingFan.Signalingmechanismsinvolvedindisusemuscleatrophy.MedHypotheses.2007,69:310–321..SCI

35.【未填作者】.Pathophysiologicalfactorsunderlyingheatstroke.MedHypotheses.2006,22(2):118-123.SCI

36.【未填作者】.Dedifferentiationofadulthumanmyoblastsinducedbyciliaryneurotrophicfactorinvitro..MolBiolCell..2005,16(7):3140-51.SCI

37.【未填作者】.Neurogenesisintheadultratbrainafterintermittenthypoxia..BrainRes..2005,1055(1-2):1-6.SCI

38.LinglingZhu,LiyingWuandMingFan..Effectsofhypoxiaonproliferationanddifferentiationofneuralstemcells.MolNeurobiology.2005,31(1-3):231-242.SCI

39.JingXT,WuHT,FanM.DIXDC1promotesretinoicacid-inducedneuronaldifferentiationandinhibitsgliogenesisinP19cells..cellmolneurobiol.2002,29:55-67.SCI

主编或副主编的著作/译著

1.《神经科学进展（第三册）》,主编,高等教育出版社,2004

2.《神经科学进展（第二册）》,主编,高等教育出版社,2003

3.《特殊环境生理学》,副主编,军事医学出版社,2003

4.《蛋白质技术手册》,主编,科学出版社,2000

重要奖项

1.适度低氧促进脑损伤修复的途径与应用方案军队科技进步二等奖201211

2.NGF临床研究北京市科技进步奖三等2008

3.兴奋毒性脑损害干预研究辽宁省科技进步一等奖2004

4.神经营养因子的系列研究北京市科技进步二等奖2003

5.海马神经元缺氧损伤机制及保护措施的研究军队科技进步二等奖1999

6.人脑源性神经营养因子基因工程及其生物学作用的研究军队科技进步二等奖1998